Research

Projects to which I have contributed (non-exhaustive).

2026

CitH3 Inhibition Attenuates Acute Ischemic Stroke via Targeted Immune Modulation

Kelvin Chen, Kyung Eun Lee, Ki Ho Park, and Jianjie Ma

University of Virginia Fozdar Symposium, Apr 2026

TL;DR PDF

The targeting of citrullinated histone H3 as a therapeutic strategy was leveraged for mitigating ischemia-activated neuroinflammation.
CitH3 Inhibition Attenuates Acute Ischemic Stroke via Targeted Immune Modulation

Kelvin Chen, Kyung Eun Lee, Ki Ho Park, and Jianjie Ma

University of Virginia Undergraduate Research Symposium, Apr 2026

TL;DR PDF

The targeting of citrullinated histone H3 as a therapeutic strategy was leveraged for mitigating ischemia-activated neuroinflammation.

2025

Co-Targeting MG53 and CitH3 Attenuates Cerebral Ischemia-Reperfusion Injury

Kelvin Chen, Kyung Eun Lee, Ki Ho Park, and Jianjie Ma

University of Virginia Fozdar Poster Session, Dec 2025

TL;DR PDF

A combination therapy approach was tested for the treatment of NETosis-mediated ischemic stroke by targeting both MG53 and CitH3.
Numerical Validation of Multi-Compartment Diffusion Biomarkers of Peripheral Nerve Trauma

Thammathida Ketsiri, Kelvin Chen, Junzhong Xu, and Richard D. Dortch

33rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, May 2025

TL;DR PDF Code

The accuracy of multi-compartmental diffusion MRI-based biomarkers was evaluated in relation to ground truth values within a simulated system for diagnosing peripheral nerve injury.

2024

Spherical Mean Diffusion-Weighted MRI Reveals Peripheral Axonal Pathology Following Trauma

Kelvin Chen, Thammathida Ketsiri, and Richard D. Dortch

Barrow Neurological Institute Undergraduate Research Symposium, Aug 2024

TL;DR PDF Code

A preclinical application of optimized spherical mean-based diffusion MRI signal simulation was used to estimate axonal volume fraction and diffusivity in rodent models of traumatic peripheral nerve injury.
Validation of Multi-Compartmental Diffusion MRI Models for Peripheral Nerve Trauma

Thammathida Ketsiri, Kelvin Chen, Junzhong Xu, and Richard D. Dortch

Gordon Research Conference on In Vivo Magnetic Resonance, Jul 2024

TL;DR PDF Code

Application of the spherical mean technique to multi-compartmental diffusion MRI models was validated for assaying the microstructural features of peripheral axons in silico following trauma.

2023

Geometry-Informed Multi-Compartmental Diffusion MRI Modeling of Sciatic Nerve Crush

Kelvin Chen, Mohammadreza S. Sadrabadi, and Richard D. Dortch

Barrow Neurological Institute Undergraduate Research Symposium, Aug 2023

TL;DR PDF Code

Computational models were constructed from nerve histology images via semantic segmentation to build a pathologically realistic dMRI-based framework for characterizing the pathology of traumatic peripheral nerve injury.