Research

2025

1. 

   Numerical Validation of Multi-Compartment Diffusion Biomarkers of Peripheral Nerve Trauma

   Thammathida Ketsiri, Kelvin Chen, Junzhong Xu, and Richard D. Dortch

   33rd Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, May 2025

   TL;DR PDF Code

   Computationally tested the accuracy of multi-compartmental diffusion MRI-based biomarkers in relation to ground truth values to assess peripheral nerve trauma.

2024

1. 

   Spherical Mean Diffusion-Weighted MRI Reveals Peripheral Axonal Pathology Following Trauma

   Kelvin Chen, Thammathida Ketsiri, and Richard D. Dortch

   Barrow Neurological Institute Undergraduate Research Symposium, Aug 2024

   TL;DR PDF Code

   A preclinical application of optimized spherical mean-based diffusion MRI signal simulation was used to estimate axonal volume fraction and diffusivity in rodent models of traumatic peripheral nerve injury.

2. 

   Validation of Multi-Compartmental Diffusion MRI Models for Peripheral Nerve Trauma

   Thammathida Ketsiri, Kelvin Chen, Junzhong Xu, and Richard D. Dortch

   Gordon Research Conference on In Vivo Magnetic Resonance, Jul 2024

   TL;DR PDF Code

   The application of the spherical mean technique to multi-compartmental diffusion MRI models was validated for assaying the microstructural complexity of peripheral axons in silico following trauma.

2023

1. 

   Geometry-Informed Multi-Compartmental Diffusion MRI Modeling of Injured Peripheral Nerves

   Kelvin Chen, Mohammadreza S. Sadrabadi, and Richard D. Dortch

   Barrow Neurological Institute Undergraduate Research Symposium, Aug 2023

   TL;DR PDF Code

   Computational models were constructed from nerve histology images via semantic segmentation to build a pathologically realistic dMRI-based framework for characterizing the pathology of traumatic peripheral nerve injury.